RESULTS: Most patients had at least one chronic comorbidity. Of these, the cardiovascular ones prevailed, hypertension being the most commonly reported comorbidity (78.5%), followed by metabolic diseases (67.5%), other respiratory disorders (54.9%) and anxiety/depression (10.0%). 110 of the 120 patients (91.6%) experienced a clinically significant improvement in distance in the 6MWT, with over 54 meters. 52.1%, 87.1%, 98.0% and 86.2% of the patients had reductions in the BMI, the scores of the CAT, breathlessness, anxiety and depression (assessed with the Hospital Anxiety and Depression Scale), parameters that correlated well with the improvement in the walking distance in the both two groups of patients. Multiple logistic regression analysis showed that respiratory failure and ischemic heart disease adversely affect the health status of these patients, especially shortness of breath, anxiety and depression.