Pulmonary Physiology: Pulmonary Physiology |

The Characteristics of Impulse Oscillometry Lung Test in Non-Specific Pattern FREE TO VIEW

Dexun Zhou, MD; Pihua Gong, MD; Yong Wang; Dong Liu; Qing Chen; Zhancheng Gao
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Peking University People's Hospital, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A484. doi:10.1016/j.chest.2016.02.504
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SESSION TITLE: Pulmonary Physiology

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Some studies have demostrated some aspects of a fairly frequent abnormal pattern of pulmonary function test results which has been term a nonspecific pattern (NSP): reduced FEV1 and FVC with a normal FEV1/FVC and normal total lung capacity. We sought to reveal the impulse osilloetry (IOS) lung test results in NSP.

METHODS: From June 22nd, 2011 to May 11th, 2015, in the database of 537 results, the NSP was found in 33 subjects. All available pulmonary function tests were examined and compared with control group with normal pulmonary function test results.

RESULTS: In NSP group, subjects were older than those in control group (64.58±12.60 vs 58.30±13.75 years, p=0.016<0.05), but the male gender, BMI, and smoking index had no significant differences to those in control group (14/33 vs 74/172, 25.09±4.28 vs 24.70±4.23kg/m2, and 0 (0∼420) vs 0 (0∼200) smoking index, respectively; p values were 0.949, 0.631, and 0.278, respectively). In NSP group, FEV1%, FEV1/FVC, inspiratory capacity, and TLC% were significantly decreased comparing to those of control group (64.99±10.13% vs 95.17±13.55%, 75.92±4.49% vs 79.72±5.07%, 1.45±0.91 vs 2.39±0.79 L, and 92.95±8.85% vs 96.65±10.64%, respectively; p values were 0.000, 0.000, 0.000, and 0.038, respectively), and Z5%, resonance frequency, R5%, R20%, and X5% were elevated (158.60 (119.50∼172.30)% vs 102.00 (84.00∼122.80)%, 21.03±4.75 vs 14.71±4.35 Hz, 141.20 (115.50∼161.20) vs 98.85 (80.15∼118.02)%, 107.32±26.87% vs 94.44±28.18%, and 349.10 (203.80∼861.20)% vs 219.35 (123.88∼446.22)%, respectively; p values were 0.000, 0.000, 0.000, 0.016, and 0.007, respectively).

CONCLUSIONS: Aging, but not gender, smoking or obesity, may play a role in NSP’s pathogenesis. According to the reduced FEV1%, FEV1/FVC, and TLC%, NSP has characteristics of obstructive and restrictive ventilation defects. The decreased inspiratory capacity of NSP revealed the impared respiratory muscle function. The elevated IOS variables, including Z5%, resonance frequency, R5%, R20%, and X5%, indicated deteriorated airway resistance and complaince in NSP.

CLINICAL IMPLICATIONS: NSP could be a precursor of some pulmonary diseases, and should be monitored regularly.

DISCLOSURE: The following authors have nothing to disclose: Dexun Zhou, Pihua Gong, Yong Wang, Dong Liu, Qing Chen, Zhancheng Gao

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