RESULTS: 34 participants were enrolled in this study. We observed a trend of decline in FEV1.0%, MMEF, FEF25 and FEF50 and rise of parameters of inpulse oscillometry. In subgroup analysis, participants were divided in to small airway dysfunction group (16) and normal control group (18) according to the pulmonary function tested in 2014. FEV1, FEF50 and MMEF declined and R5∼R15 rised in small airway dysfunction group, while the opposite outcome was found in normal control group (p<0.01). The 6-year change of FEV1 was positively correlated with the baseline level of vWF, MDA and the variation rate of FEV1 around 2008 Olympic Games (p<0.05). Besides, 6-year changes of FEF25 was negatively correlated with the baseline of FEF25, MMEF and was positively correlated with baseline level of vWF (p<0.05). There was also a positive correlation between the baseline of pulmonary resistance parameters with their longitudinal changes. Multivariate regression analysis shows the high level of vWF tested in 2008 leaded to the rise of FEV1 in 6 years (β=0.446, p=0.018). We also found the level of particulate matter (PM2.5) in Beijing decreased during these years.