Pulmonary Physiology: Pulmonary Physiology |

A Study on Long-Term Changes of Pulmonary Function in Healthy Young Adults in Beijing FREE TO VIEW

Ling-xiao Zhou; Guangfa Wang; Jiping Liao
Author and Funding Information

The First Hospital of Peking University, Hangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A482. doi:10.1016/j.chest.2016.02.502
Text Size: A A A
Published online

SESSION TITLE: Pulmonary Physiology

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To figure out the longitudinal changes of pulmonary function and inpulse oscillometry of healthy young adults from 2008 to 2014 in Beijing, China, and to explore the correlation between the baseline parameters of pulmonary function, levels of inflammatory cytokines with the long-term changes of pulmonary function.

METHODS: Participants who attended the HEART study during 2008 Beijing Olympic Games were invited to retest pulmonary function after screened. We analyzed the changes in pulmonary functions during these years, and investigate the changes in levels of ambient air pollution in Beijing.

RESULTS: 34 participants were enrolled in this study. We observed a trend of decline in FEV1.0%, MMEF, FEF25 and FEF50 and rise of parameters of inpulse oscillometry. In subgroup analysis, participants were divided in to small airway dysfunction group (16) and normal control group (18) according to the pulmonary function tested in 2014. FEV1, FEF50 and MMEF declined and R5∼R15 rised in small airway dysfunction group, while the opposite outcome was found in normal control group (p<0.01). The 6-year change of FEV1 was positively correlated with the baseline level of vWF, MDA and the variation rate of FEV1 around 2008 Olympic Games (p<0.05). Besides, 6-year changes of FEF25 was negatively correlated with the baseline of FEF25, MMEF and was positively correlated with baseline level of vWF (p<0.05). There was also a positive correlation between the baseline of pulmonary resistance parameters with their longitudinal changes. Multivariate regression analysis shows the high level of vWF tested in 2008 leaded to the rise of FEV1 in 6 years (β=0.446, p=0.018). We also found the level of particulate matter (PM2.5) in Beijing decreased during these years.

CONCLUSIONS: FEV1 declines earlier and resistance increases earlier for young adults with small airway dysfunction. Baseline of pulmonary function and vWF could predict the longitudinal changes of pulmonary function. Influences of air pollution on pulmonary function are reversible in healthy young adults after improvement of ambient air pollution, and those whose pulmonary function were more sensitive to air pollution could benefit more.

CLINICAL IMPLICATIONS: This study provided evidence that the pulmonary function of healthy young adults could be predicted, and pulmonary function of healthy young adults could benefit from improvement of air pollution.

DISCLOSURE: The following authors have nothing to disclose: Ling-xiao Zhou, Guangfa Wang, Jiping Liao

No Product/Research Disclosure Information




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543