Pulmonary Manifestations of Systemic Disease: Pulmonary Manifestations of Systemic Disease |

Reassess the Value of 18F-FDG PET/CT for Relapsing Polychondritis Diagnose and Therapeutic Response Monitoring FREE TO VIEW

Yuan Luo, MD; Jinlin Wang, MD; Xiaohong Xie, MD; Yunxiang Zeng, MD; Shiyue Li, MD
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The State Key Laboratory of Respiratory Disease, China Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A465. doi:10.1016/j.chest.2016.02.484
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SESSION TITLE: Pulmonary Manifestations of Systemic Disease

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 08:30 AM - 09:30 AM

PURPOSE: Relapsing polychondritis (RP) is relatively rare. Recently, our previous investigation and other studies have revealed that 18F-FDG PET/CT is a useful early diagnostic tool, it is valuale in guiding the selection of a biopsy site and monitoring the therapeutic response. In the present study, we retrospectively investigated the biggest case datas and reassessed the value of 18F-FDG PET/CT for RP

METHODS: Nineteen RP patients undering 18F-FDG PET/CT at the First Affiliated Hospital of Guangzhou Medical University were reviewed from 2010 to 2015, follow-up scans were performed during therapy in ten patients. Datas from the patients were analysed.

RESULTS: Typical FDG uptake was noted in tracheobronchial trees (n=17), nasal cartilage (n = 15), arytenoid cartilage (n = 13), cricoid cartilage (n = 12), auricular cartilage (n = 12), costicartilage (n = 10), thyroid cartilage (n = 8), hyoid cartilage (n = 7) and mediastinum lymph node (n = 2). One patient showed FDG uptake only in cricoid cartilage, another showed no any FDG uptake. PET/CT-guided biopsy were performed in ten patients (three in nasal cartilage, seven in auricular cartilage). Biopsies of auricular cartilage in other five patients were positive but no FDG uptake. Biopsies of the tracheal/bronchial walls by bronchoscopy were all negative even though FDG uptakes increased in 17 patients. The intense uptake reduced or disappeared during steroid therapy for eight patients. In other two followed-up patients with symptomatic and inflammatory improvement, most FDG uptakes had diminished but two sides increased.

CONCLUSIONS:18F-FDG PET/CT plays a valuable role in assessing almost cartilages and detecting early or atypical RP, but the role of the selection of a biopsy site as well as therapeutic response monitoring must be further discussed.

CLINICAL IMPLICATIONS:18F-FDG PET/CT can be use to assess almost cartilages and detect early or atypical RP.

DISCLOSURE: The following authors have nothing to disclose: Yuan Luo, Jinlin Wang, Xiaohong Xie, Yunxiang Zeng, Shiyue Li

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