Pulmonary Manifestations of Systemic Disease: Mechanisms of Pulmonary Fibrosis |

Role of Soluble Receptor for Advanced Glycation End Products on Bleomycin-Induced Lung Fibrosis in Mice FREE TO VIEW

Mei He, PhD; Ruiling Liu; Qiang Chen, MD; Hanjing Lv; Zhongmin Qiu, PhD
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Tongji Hospital, Tongji University School of Medicine, Shanghai, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A455. doi:10.1016/j.chest.2016.02.474
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SESSION TITLE: Mechanisms of Pulmonary Fibrosis

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 09:45 AM - 11:15 AM

PURPOSE: The aim of this study was to examine the effect of recombinant (sRAGE) on bleomycin-induced lung fibrosis in mice.

METHODS: Bleomycin-induced lung fibrosis was evaluated in the mice with or without intraperitoneal administration of sRAGE. Lungs were sampled for histopathology and BAL fluid was collected for cell counting and measurements of lung permeability and cytokine concentrations. Effects of sRAGE on HMGB-1 induced epithelial-mesenchymal transition (EMT) in alveolar type II epithelial cells were evaluated.

RESULTS: Treatment with sRAGE significantly attenuated the increases in neutrophil infiltration, lung permeability, production of inflammatory cytokines and development of pathologic changes after bleomycin instillation. Alveolar type II epithelial cells treated with sRAGE did not respond to HMGB-1 induced epithelial-mesenchymal transition (EMT).

CONCLUSIONS: Our results suggested that sRAGE protected from bleomycin-induced lung fibrosis in mice through EMT and profibrotic cytokine.

CLINICAL IMPLICATIONS: sRAGE might be a new therapeutic target for pulmonary fibrosis.

DISCLOSURE: Mei He: Employee: received a payment for services Ruiling Liu: Employee: have received a payment for services Qiang Chen: Employee: received a payment for services Hanjing Lv: Employee: have received a payment for services Zhongmin Qiu: Employee: received a payment for services

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