SESSION TITLE: Mechanisms of Pulmonary Fibrosis
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Sunday, April 17, 2016 at 09:45 AM - 11:15 AM
PURPOSE: The aim of this study was to examine the effect of recombinant (sRAGE) on bleomycin-induced lung fibrosis in mice.
METHODS: Bleomycin-induced lung fibrosis was evaluated in the mice with or without intraperitoneal administration of sRAGE. Lungs were sampled for histopathology and BAL fluid was collected for cell counting and measurements of lung permeability and cytokine concentrations. Effects of sRAGE on HMGB-1 induced epithelial-mesenchymal transition (EMT) in alveolar type II epithelial cells were evaluated.