0
Pulmonary Manifestations of Systemic Disease: Mechanisms of Pulmonary Fibrosis |

Surfactant Protein-A Nanobody-Conjugated Liposomes Loaded With Methylprednisolone for Lung Targeting and Therapeutic Effect for Acute Lung Injury

Huiping Li, MD
Author and Funding Information

Shanghai Pulmonary Hospital, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A454. doi:10.1016/j.chest.2016.02.473
Text Size: A A A
Published online

Extract

SESSION TITLE: Mechanisms of Pulmonary Fibrosis

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 09:45 AM - 11:15 AM

PURPOSE: To develop a lung-targeting glucocorticoid that could exert its function mainly in the lung tissues, thereby reducing the toxic side effects on other organs.

METHODS: Methylprednisolone (MPS) was used as the treatment drug, and nano-sterically stabilized liposomes (NSSLs) were used as carriers to form the MPS-NSSLs particle. The MPS-NSSLs particle was further conjugated to nanobodies of surfactant protein A (SPANb) to make MPS-NSSLs-SPANb. The characteristics of MPS-NSSLs-SPANb particles were evaluated. Small animal imaging was performed in nude mice to analyze the distribution of MPS-NSSLs-SPANb in vivo, and the content of MPS in the different organs of rats was measured at different time points to verify the lung-targeting property of MPS-NSSLs-SPANb. The safety and therapeutic effect of MPS-NSSLs-SPANb were evaluated in rats with bleomycin-induced lung injury.

First Page Preview

View Large
First page PDF preview

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

MEMBER & INDIVIDUAL SUBSCRIBER

Want Access?

NEW TO CHEST?

Become a CHEST member and receive a FREE subscription as a benefit of membership.

Individuals can purchase this article on ScienceDirect.

Individuals can purchase a subscription to the journal.

Individuals can purchase a subscription to the journal or buy individual articles.

Learn more about membership or Purchase a Full Subscription.

INSTITUTIONAL ACCESS

Institutional access is now available through ScienceDirect and can be purchased at myelsevier.com.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543