RESULTS: 95% patients had underlying disease or immunosuppression. Diabetes mellitus (66.7%), diabetes ketoacidosis (21.7%), corticosteroid therapy (20%), kidney indufficiency (18.3%) were the most common predisposing factors reported. 5.1% cases were asymptomatic at the time of diagnosis. 28.6% had negative physical finding. 44.7% cases had normal blood tests, only 13.2% had neutropenia which mostly among non-diabetic patients (p=0.006). Merely 23.2% large bronchi were involved in imaging studies, single mass was the most form observed (33.9%). Most histopathologic diagnosis had been made by transbronchial biopsy (76.7%). Angioinvasion were found in 35% patients. Rhizopus was the predominant species (66.7%). Primary bronchus were the most frequent location involved (38.2%); the bronchial stenosis and necrotic material form were the most commonly observed (40%,34.5% respectively) and the latter was more frequent in diabetic patients (p = 0.047). There was a predilection for involvement of the upper lobes (51% of cases). The most frequent antifungal therapy were intravenous amphotericin B deoxycholate (AmB) or AmB aerosolized (79.7% totally), surgery (33.3%), and AmB combined surgery (28.3%). Overall inhospital mortality was 52.5%, with hemoptysis (odds ratio (OR)=26.68; p=0.017), dyspnea at presentation (OR=31.47; p=0.022) and angioinvasion (OR=12.21; p=0.03) as independent risk prognostic factors, whereas surgery (OR=0.032; p=0.003) was an independent protection prognostic factor.