Procedures: Procedures |

Value of Endobronchial Optical Coherence Tomography in Identifying Small Airway Remodeling in Patients With COPD FREE TO VIEW

Yu Chen, MD; Ming Ding, MD; Wei-jie Guan, MD; Changhao Zhong, MD; Weizhan Luo, MD; Nanshan Zhong, MD; Shiyue Li, MD
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The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A450. doi:10.1016/j.chest.2016.02.468
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SESSION TITLE: Pulmonary Procedures

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 09:45 AM - 11:15 AM

PURPOSE: To evaluate the value of OCT in identifying small airway lesions in patients with COPD.

METHODS: A total of 130 patients undergoing bronchoscopy owing to pulmonary opacity or infection were recruited. According to their medical history, PFT and chest CT, these patients were divided into the normo-PFT non-smoking group, normo-PFT smoking group or the COPD group. In the three groups, 0.9mm OCT imaging catheters were advanced into third- to ninth-generation sub-segmental bronchi of the both lower lungs (B8 and B9) through an ultrathin bronchoscope under guidance of virtual bronchoscopic navigation (VBN) for continuous OCT scan. Image-based measurement was used to compare the size of lumen, wall thickness and wall structure of these bronchi among the three groups.

RESULTS: The 130 patients comprised 81 male and 49 female subjects with a mean age of 53.3±16.3 years old. Nonsmokers with normal lung function, lung function normal smokers, COPD patients was no significant difference in the OCT measuring Dir 3 to generation 4 bronchial diameter, 5 to 9 bronchial diameter were significantly different; the three groups EB-OCT measurements of patients at generation 3 to 5 bronchus, three groups of patients without bronchial bronchial lumen diameter and statistically significant differences in terms of the area; in the first 6 to 9 bronchus, three groups of patients had bronchial diameter significant difference: COPD group <smokers with normal lung function <pulmonary non-smoking group (P <0.05); in 3 to 9 bronchus, bronchial wall mucosa and bronchial wall area percentage terms mucosal area three groups of patients were There are significant differences: COPD group> smokers with normal lung function> lung function non-smoking group (P <0.05);

CONCLUSIONS: EB-OCT imaging can accurately measure the lumen diameter and cross-sectional area from generation 3 to 9 bronchi. EB-OCT imaging measurements of small airways for bronchial lumen diameter and area comparisons results: COPD group <normo-PFT smoking group<normo-PFT non-smoking group; bronchial wall mucosa area (WMA) and wall area mucosal percentage (WMA%) comparisons results: COPD group> normo-PFT smoking group> normo-PFT non-smoking group.

CLINICAL IMPLICATIONS: The abilities of EB-OCT imaging findings identifiying characteristic of COPD, such as diminished diameter of lumen, thickening of intima andobscure visualization of lumen-intimaboundary, may help to suggest the early-stage COPD.

DISCLOSURE: The following authors have nothing to disclose: Yu Chen, Ming Ding, Wei-jie Guan, Changhao Zhong, Weizhan Luo, Nanshan Zhong, Shiyue Li

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