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Procedures: Procedures |

Validation of Human Small Airway Measurements Using Endobronchial Optical Coherence Tomography FREE TO VIEW

Yu Chen, MD; Ming Ding, MD; Wei-jie Guan, MD; Shiyue Li, MD; Nanshan Zhong, MD
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The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A446. doi:10.1016/j.chest.2016.02.464
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SESSION TITLE: Pulmonary Procedures

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 09:45 AM - 11:15 AM

PURPOSE: To evaluate the usefulness of endobronchial optical coherence tomography (EB-OCT) in assessing small airways morphology in vivo.

METHODS: Twelve patients with pulmonary nodules scheduled for lung resection underwent spirometry, multidetector computed tomography (MDCT) and EB-OCT. We measured Dmean (mean luminal diameter), Ai (inner luminal area), Aw (airway wall area) and Aw% [Aw/(Ai+Aw) ×100%] from the 3rd to 5th generation bronchi of RB9 segment by MDCT. Dmean, Ai, Aw and Aw% from the 3rd to 9th generation bronchi of RB9 segment were measured by EB-OCT and histology. The correlations of these 4 parameters, measured by the three methods, were evaluated.

RESULTS: EB-OCT was well tolerated. The 4 parameters, measured by CT and EB-OCT, correlated significantly [Dmean (r=0.991), Ai (r=0.997), Aw (r=0.997), Aw% (r=0.991), all P<0.01]. Significant correlation were found for the 4 parameters, measured by histology and EB-OCT, from the 3rd to 5th generation bronchi [Dmean (r=0.989), Ai (r=0.997), Aw (r=0.999), Aw% (r=0.988), all P<0.01], and from the 6th to 9th generation bronchi [Dmean (r=0.979), Ai (r=0.997), Aw (r=0.994) and Aw% (r=0.988), all P<0.01]. Significant morphological small airways abnormalities were observed in COPD patients.

CONCLUSIONS: EB-OCT, a direct and minimally invasive imaging modality with high-resolution, is useful for assessment of proximal and distal airways compared with CT (for larger airways) and histology.

CLINICAL IMPLICATIONS: This technique offers a direct, minimally invasive and high-resolution imaging modality for future investigations which will help understand the pathophysiology of various lung diseases, and hopefully aid us assess outcomes of new treatments for disorders affecting the small airways.

DISCLOSURE: The following authors have nothing to disclose: Yu Chen, Ming Ding, Wei-jie Guan, Shiyue Li, Nanshan Zhong

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