METHODS: FAK and IGF-1R in pleural effusion (BPE) and malignant pleural effusion (MPE) were detected by ELISA. The FAK and IGF-1R mRNA were measured by RT-PCR;The expression of IGF-1R, FAK, pIGF-1R, pFAK were detected through Western-blot. The effection of TAE226 on cell migration, invasion, apoptosis were tested by Matrigel Invasion Assay, Wound healing and TUNEL. We established an orthotopic transplantation model of MPE in SCID mice by injecting A549 cells thoracically. We watched gross morphology of tumor tissue in HE staining, assayed CD31 and ki67 expression in tumors tissue in Immunohistochemical staining.