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Procedures: Procedures: Pleura |

Experimental Study of Focal Adhesion Kinase (FAK) and Insulin-Like Growth Factor-I Receptor (IGF-1R) in Malignant Pleural Effusions

Shun Liu; Wei Zhang; Yi Huang; Feng Wu; Lan Zhu; Ling Gong; Chuan Huang
Author and Funding Information

The Institute of Respiratory Diseases in Zunyi City, The First People's Hospital of Zunyi City, Zunyi, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A444. doi:10.1016/j.chest.2016.02.462
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SESSION TITLE: Procedures: Pleura

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: This study is aimed to explore the role of focal adhesion kinase (FAK) and the insulin- like growth factor-I receptor (IGF-1R) in malignant pleural effusion (MPE).

METHODS: FAK and IGF-1R in pleural effusion (BPE) and malignant pleural effusion (MPE) were detected by ELISA. The FAK and IGF-1R mRNA were measured by RT-PCR;The expression of IGF-1R, FAK, pIGF-1R, pFAK were detected through Western-blot. The effection of TAE226 on cell migration, invasion, apoptosis were tested by Matrigel Invasion Assay, Wound healing and TUNEL. We established an orthotopic transplantation model of MPE in SCID mice by injecting A549 cells thoracically. We watched gross morphology of tumor tissue in HE staining, assayed CD31 and ki67 expression in tumors tissue in Immunohistochemical staining.

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