Procedures: Procedures: Pleura |

Pleurodesis With Povidone-Iodine Versus Talc in Malignant Pleural Effusion: A Retrospective Study FREE TO VIEW

Xi Wang, MD; Guangfa Wang, MD; Hong Zhang, MD; Wei Zhang
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Peking University First Hospital, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A442. doi:10.1016/j.chest.2016.02.460
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SESSION TITLE: Procedures: Pleura

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Chemical pleurodesis is the best available treatment for malignant pleural effusion when the underlying cause cannot be cured. Talc is considered the most effective chemical agent for MPE, but the availability of medical grade talc remains a constraint in China. Povidone-iodine is an inexpensive and easily available topical antiseptic, it has been shown to be an effective and safe sclerosing agent for chemical pleurodesis. The purpose of our study is to compare the efficacy and safety of povidone-iodine with talc for pleurodesis in patients with MPE admitted in Peking University First Hospital during 2008-2015.

METHODS: Thirty-four patients were included, fourteen received thoracoscopic talc poudrage, whereas twenty patients underwent pleurodesis by instilling povidone-iodine at the end of diagnostic thoracoscopy or through a thoracostomy tube.

RESULTS: The mean age was 68.9 ± 10.5 (range: 41-87) years, the complete and partial response was abtained in 78.6% of talc group and 70.0% of povidone-iodine group which was not statistically significant (P=0.467). Post-procedure fever was higher in povidone-iodine group (80.0% vs 28.6%, P=0.005), but chest pain had no statistical difference (78.6% vs 50.0%, P=0.153). Two patients (10%) experienced systemic hypotension after the instillation of povidone-iodine. There was no in-hospital death associated with the procedure.

CONCLUSIONS: Povidone-iodine is a good alternative to talc to ensure effective pleurodesis for patients with malignant pleural effusion.

CLINICAL IMPLICATIONS: The availability of medical grade talc remains a constraint in China, our study show that povidone-iodine is a good alternative to talc as it is cheap, easily available, effective and safe.

DISCLOSURE: The following authors have nothing to disclose: Xi Wang, Guangfa Wang, Hong Zhang, Wei Zhang

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