Procedures: Procedures: Pleura |

Thoracoscopic Pleurodesis Using Doxycycline Poudrage in Malignant Pleural Effusion FREE TO VIEW

Eman Hatata, PhD; Rasha Daabis, PhD; Bassma ElSabaa, PhD; Ayman Baess, PhD; Inas Abd El-Rahman, MS
Author and Funding Information

Chest Department, Alexandria Faculty of Medicine, Alexandria, Egypt

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A437. doi:10.1016/j.chest.2016.02.455
Text Size: A A A
Published online

SESSION TITLE: Procedures: Pleura

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To assess the efficacy, safety and outcome of thoracoscopic poudrage using oral forms of doxycycline in malignant pleural effusion (MPE)

METHODS: We enrolled 30 patients with MPE. Medical thoracoscopic pleurodesis was performed using oral doxycycline. Patients were observed for 90 days after the procedure. Efficacy was judged both clinically and radiologically. Procedure-related complications were recorded.

RESULTS: Patients were 20 males and 10 females. Mean age ±SD was 57.67 ± 13.29 years. The most common primary neoplasms were lung cancer and breast cancer (both, n =11). After 90 days, 19 out of 22 surviving patients (86.4%, 95%CI=59.8 - 94.8%) had successful pleurodesis. No procedure-related major complications were recorded. Minor adverse effects included pain (28.6%), fever (25%) and wound infection (10.7%). Survival rate at 90 days was 78.6%. Mean duration of hospitalization was 1.93 ± 0.92 days.

CONCLUSIONS: Thoracoscopic doxycycline poudrage is a safe and effective method of pleurodesis in recurrent malignant pleural effusions.

CLINICAL IMPLICATIONS: As talc is not available in many countries, Thoracoscopic doxycycline poudrage is an efficacious and safe alternative for pleurodesis in malignant pleural effusion.

DISCLOSURE: The following authors have nothing to disclose: Eman hatata, Rasha Daabis, Bassma ElSabaa, Ayman Baess, Inas Abd El-Rahman

We used doxycycline 100 mg cap (Vibramycin 100 mg cap, Pfizer inc.) for pleurodesis through thoracoscopic poudrage. This is an off label indication. Doxycycline is widely known sclerosing agent in its parental form for pleurodesis. Selected reports showed the efficacy of oral doxycycline when dissolved and performing pleurodesis via slurry. To the best of authors' knowledge, this method was described before in a poster in a previuos ATS conference but many concerns regarding the methodology & study design were taken against.




Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543