RESULTS: between Aug. 2014 and Jul. 2015, 54 consecutive patients with PPLs, who were referred to our hospital for diagnostic bronchoscopy, were included after written informed consent. 47 PPLs identified by REBUS underwent REBUS-GS-TBB and REBUS-D-TBB. The diagnostic yield was 83.0% (39/47, GS group) and 87.2% (41/47, D group) respectively (P=0.158). The mean biopsy time after visualization of PPLs was reduced in GS group [5.17 ± 2.34 (min) vs. 7.36 ± 3.18 (min), P=0.00053]. 5 cases of bleeding >50 ml were observed in REBUS-D-TBB group and none in REBUS-GS-TBB group. Pneumothorax was not occurred in this study.