Occupational and Environmental Lung Diseases: Occupational and Environmental Lung Diseases |

Right Ventricular Echocardiographic Parameters in Workers Exposed to Metal Pollutants FREE TO VIEW

Ligia Puiu, MD; Oana Claudia Deleanu, PhD; Calin Pop, MD; Anca Petrovan, MD; Florin Dumitru Mihaltan, MD; Oana Arghir, MD
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Hospital of Pneumophthisiology, Baia-Mare, Romania

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A414. doi:10.1016/j.chest.2016.02.430
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SESSION TITLE: Occupational and Environmental Lung Diseases

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To identify changes in right ventricular (RV) Echocardiographyc Parameters and to assess possible correlations with biomarkers of inflammation at workers exposed to metal pollutants on historical mines areas in the North-Western part of Romania. Chronic occupational exposure to these pollutants with polymetallic texture could generate by redox inactive or active metals, reactive oxygen, nitrogen and halogen species by direct or indirect Fenton/Haber-Weiss reactions, enhanced lipid peroxidation leading to oxidative stress.

METHODS: A follow-up prospective study of 40 cases mean aged 43.77±4.94 years, with a mean period of heavy metals (HM) exposure of 16.7±4.44 years versus 26 nonexposed individuals mean aged 50.15±5.36 years was performed. Demographic, anthropometric, plasma lipid profile {(total cholesterol-TC, low density lipoprotein cholesterol-LDLc, high density lipoprotein cholesterol-HDLc, triglycerides-TG, nonhigh density lipoprotein cholesterol-nonHDLc, very low density lipoprotein cholesterol-VLDL), by which were calculated lipid indices}, apolipoprotein B100 (apoB100), glycemia, C-Reactive Protein (CRP), urea and creatinin levels were performed. All subjects underwent echocardiography. Statistical analysis included Spearman correlations tests and one-way ANOVA test.

RESULTS: The medium systolic pulmonary artery pressure (mSPAP) and atherogenic indices (TG/HDLc and VLDL/HDLc ratios) were statistically significant higher in the study group versus controls (p>0.03;p>0.0001;p>0.05 respectively). In cases, correlations were found between CRP and mSPAP (r=−0.35;p=0.02), tricuspidian regurgitation (r=−0.33;p=0.03); apoB100 and RV wall thickness (r=0.58;p=0.0001), RV basal medium axis diameter (r=0.50;p=0.0009).

CONCLUSIONS: The HM released during mining exploration activities may promote changes of RV echocardiographyc parameters related to dyslipidemia and atherosclerosis increasing cardiovascular risk.

CLINICAL IMPLICATIONS: The HM contamination represents a modifiable health risk factor and RV echocardiographyc appraisal has to be recommended to all metal miners employees.

DISCLOSURE: The following authors have nothing to disclose: Ligia Puiu, Oana Claudia Deleanu, Calin Pop, Anca Petrovan, Florin Dumitru Mihaltan, Oana Arghir

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