SESSION TITLE: Occupational and Environmental Lung Diseases
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Urban environments have high ambient particulates and a coexisting high prevalence of metabolic syndrome. The contribution of these two conditions to pulmonary disease is a topic of considerable importance. RAGE is highly expressed in the lung and is a strong predictor of FEV in genome wide association studies. We established a murine model of high intensity PM exposure and quantified lung function after 24 hours and 28 days. We also investigated if loss of RAGE is protective against PM-induced lung injury. We also looked for histopathologic changes in lung architecture between wild-type mice and RAGE-/- that aspirated WTC-PM at both time points.