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Occupational and Environmental Lung Diseases: Occupational and Environmental Lung Diseases |

Receptor for Advanced Glycation End Products (RAGE) Contributes to World Trade Center Particulate Matter (WTC-PM)-Associated Lung Function Loss

Sophia Kwon, DO; Erin Caraher, BS; Hissam Haider, MBBS; George Crowley; Audrey Lee; David Prezant; Anna Nolan, MD
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NYU, New York, NY


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A408. doi:10.1016/j.chest.2016.02.424
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SESSION TITLE: Occupational and Environmental Lung Diseases

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Urban environments have high ambient particulates and a coexisting high prevalence of metabolic syndrome. The contribution of these two conditions to pulmonary disease is a topic of considerable importance. RAGE is highly expressed in the lung and is a strong predictor of FEV in genome wide association studies. We established a murine model of high intensity PM exposure and quantified lung function after 24 hours and 28 days. We also investigated if loss of RAGE is protective against PM-induced lung injury. We also looked for histopathologic changes in lung architecture between wild-type mice and RAGE-/- that aspirated WTC-PM at both time points.

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