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Occupational and Environmental Lung Diseases: Occupational and Environmental Lung Diseases |

Treg/Th17 Cells in Chronic Lung Inflammation Models Exposed to PM2.5 in Beijing China

Xue Xia, MD; Guangfa Wang, PhD
Author and Funding Information

Peking University First Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A407. doi:10.1016/j.chest.2016.02.423
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SESSION TITLE: Occupational and Environmental Lung Diseases

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Both T helper interleukin 17 (IL-17)-producing cells (Th17 cells) and regulatory T cells (Tregs) have been found to be increased in human asthma however, the possible interaction between Th17 cells and Tregs in other airway inflammation disease remains to be elucidated. The objective of our study was to investigate the distribution of Th17 cells in relation to Tregs, as well as the mechanism of Tregs in regulating generation and differentiation of Th17 cells in airway inflammation related to PM2.5, and also to explore the differentiation and immune regulation of Treg and Th17 cells in the development of PM2.5 exposure related in mice models.

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