Occupational and Environmental Lung Diseases: Occupational and Environmental Lung Diseases |

Treg/Th17 Cells in Chronic Lung Inflammation Models Exposed to PM2.5 in Beijing China FREE TO VIEW

Xue Xia, MD; Guangfa Wang, PhD
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Peking University First Hospital, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A407. doi:10.1016/j.chest.2016.02.423
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SESSION TITLE: Occupational and Environmental Lung Diseases

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Both T helper interleukin 17 (IL-17)-producing cells (Th17 cells) and regulatory T cells (Tregs) have been found to be increased in human asthma however, the possible interaction between Th17 cells and Tregs in other airway inflammation disease remains to be elucidated. The objective of our study was to investigate the distribution of Th17 cells in relation to Tregs, as well as the mechanism of Tregs in regulating generation and differentiation of Th17 cells in airway inflammation related to PM2.5, and also to explore the differentiation and immune regulation of Treg and Th17 cells in the development of PM2.5 exposure related in mice models.

METHODS: In our study, the numbers of Th17 cells and Tregs in BALF and blood were determined by flow cytometry, and the expressions of Th17- and Treg-related cytokines in serum were measured by enzyme-linked immunosorbent assay (ELISA). The regulationand mechanism of Tregs on generation and differentiation of Th17 cells were explored.

RESULTS: Our data demonstrated that the numbers of Th17 cells were increased in the BALF of PM2.5 exposured mice compared with blood, Th17 cell numbers were correlated negatively with Tregs in the model but not in blood.

CONCLUSIONS: Our study shows that Th17/Treg imbalance exists in lung inflammation and that Tregs could inhibit generation and differentiation of Th17 cells.

CLINICAL IMPLICATIONS: th17/treg might be a potential intervention pathways related to air pollution particles lung immune system

DISCLOSURE: The following authors have nothing to disclose: Xue Xia, Guangfa Wang

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