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Obstructive Lung Diseases: COPD Phenotypes |

A Distinct Phenotype in Chronic Obstructive Pulmonary Disease: COPD Caused by Biomass Smoke FREE TO VIEW

Dongxing Zhao, MDS; Yumin Zhou, MDS; Changbin Jiang, MDS; Xiaochen Li, MDS; Zhuxiang Zhao, MDS; Fang He, MDS; Sha Liu; Jinding Pu; Pixin Ran, MDS
Author and Funding Information

State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A399. doi:10.1016/j.chest.2016.02.414
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SESSION TITLE: COPD Phenotypes

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate the clinical phenotype in patients with COPD caused by biomass smoke.

METHODS: The subjects were grouped according to the risk factors exposured: ① COPD group caused by biomass smoke (BSCOPD), ② COPD group caused by cigarette smoke (CSCOPD), ③ Normal control group exposed by biomass smoke (BSNormal), ④ Normal control group exposed by cigarette smoke (CSNormal). All subjects completed a questionnaire regarding demographic data, symptoms, and environmental exposure and underwent spirometry, HRCT of the chest, bronchial mucosal biopsies and bronchoalveolar lavage fluid (BALF). The clinical variables of four groups were compared.

RESULTS: There were 29 subjects in BSCOPD,31 in CSCOPD,12 in BSNormal and 10 in CSNormal. Phenotype of pulmonary function:Vcmax% pred and FVC% pred in BSCOPD were greater than that in CSCOPD (P=0.013). PEF25, PEF50, PEF75, MMEF in BSCOPD were less than those in CSCOPD (P<0.05). PEF25, PEF50, PEF75, MMEF, MMEF% pred in BSCOPD and CSCOPD were less than those in control groups (p<0.01). FEV1% pred and FEV1/FVC in BSCOPD and CSCOPD were less than those in control groups (p<0.05) but there was no significant difference between BSCOPD and CSCOPD. Phenotype of HRCT: EI and GVin% in BSCOPD were significantly less than those in CSCOPD (P<0.01). EI and GV in% in BSCOPD and CSCOPD were significantly greater than those in control groups (p<0.05). RVC-860to-950HU in BSCOPD was significantly less than that in CSCOPD (P<0.01). Pathological features:basement membrane thickness of BSCOPD was significantly thicker than CSCOPD and control groups (P<0.01). The basement membrane thickness of CSCOPD had no significant difference with control groups (P>0.05). Endobronchial pigmentation in BSCOPD was significantly more than that in CSCOPD (P<0.05). The proportions of macrophages and lymphocytes of BALF in BSCOPD were significantly greater than those in CSCOPD. The proportion of neutrophils of BALF in BSCOPD was significantly less than that in CSCOPD (P<0.05).

CONCLUSIONS: COPD caused by biomass smoke is a distinct phenotype of COPD, with different clinical, radiological, pathological and physiological characteristics compared with COPD caused by cigarette smoke.

CLINICAL IMPLICATIONS: COPD caused by biomass smoke maybe have different prognosis or treatment characteristics compared with COPD caused by cigarette smoke.

DISCLOSURE: The following authors have nothing to disclose: Dongxing Zhao, Yumin Zhou, Changbin Jiang, Xiaochen Li, Zhuxiang Zhao, Fang He, Sha Liu, Jinding Pu, Pixin Ran

No Product/Research Disclosure Information


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