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Obstructive Lung Diseases: COPD Phenotypes |

Association of IL-6 and IL-6R Gene Polymorphisms and Decline of FEV1 in Shichahai Community in the Center of Beijing FREE TO VIEW

Cuiyan Guo; Guangfa Wang; Yanni Zhao; Xi Wang; Cheng Yuan
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Peking University First Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A398. doi:10.1016/j.chest.2016.02.413
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SESSION TITLE: COPD Phenotypes

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: COPD is a worldwide public health concern. The rapid decline in FEV1 is one of the core pathological features of COPD. Genetic polymophysim may predict the rapid decline of FEV1. To date there is no study on the genetic susceptibility correlated to rapid FEV1 decline among Chinese population. IL-6 is a key cytokine in the inflamatory process. The polymorphisms of IL-6/IL-6R gene may influence the progress of inflammation and correlates with the rapid decline of FEV1

METHODS: Subjects were from a prospective cohort study previously established in Shichahai community. Whole blood specimens were collected and spirometry was measured at the first visit. Two years later, spirometry was repeated. Five SNPs of IL-6 gene and two SNPs of IL-6 receptor were selected for genotyping

RESULTS: 1, 452 subjects fulfilled the inclusion criteria and finished the 2nd visit, with an average age of (58.8±8.6) years, 29% male and 71% female. The mean decline rate of FEV1 in the cohort was (43±114) ml per year. 2, A mean decline of FEV1 by (64±125) ml per year was observed in smokers whereas the decline rate in non-smokers was (36±109) ml per year, (P=0.030). However, smoking cessation did not influence the decline rate of FEV1. Moderate to heavey smokers (SI>200) had a faster FEV1 decline than non-smokers or mild smokers (SI≤200). Multivariate Linear regression analysis revealed smoking history as an independent factor associated with FEV1 decline rate. 3, The MAF of the targetted 7 SNPs (rs1800796/rs2069837/rs1524107/rs2069840/rs1818879/rs4129267//rs4845374) were (0.31/0.21/0.34/ 0.08/0.26/0.42/0.11), in order. Among the 7 SNPs, there was no genotype correlated to FEV1 decline. However, through the analysis of the Haploview, the frequency of rs1800796G and rs1524107C were lower in the rapid FEV1 decline group, (OR= 0.70, P= 0.028 and OR=0.69, p=0.015 respectively). The haplotype CATG (rs1800796/rs2069837/rs1524107/rs2069840) was significantly correlated with rapid FEV1 decline, (P=0.047), with frequency of 0.647

CONCLUSIONS: 1, The mean rate of FEV1 decline in the community population in the urban area of Beijing was (43±114) ml per year. 2, Smoking was an independent risk factor for rapid FEV1 decline. FEV1 decline rate may be positively related with smoking index. 3, The polymorphisms of IL-6 gene may be related to the decline rate of FEV1

CLINICAL IMPLICATIONS: It is the first attempt to seek gene factors affected decline of FEV1 in Chinese people

DISCLOSURE: The following authors have nothing to disclose: Cuiyan Guo, Guangfa Wang, Yanni Zhao, Xi Wang, Cheng Yuan

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