0
Obstructive Lung Diseases: COPD Phenotypes |

Treatment of Corticosteroids Combined With Theophylline in COPD Based on HRCT Phenotypes FREE TO VIEW

Xian Wen Sun; Qing Yun Li; Shu Yi Gu; HuanYing Wan; Shao Guang Huang
Author and Funding Information

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A397. doi:10.1016/j.chest.2016.02.412
Text Size: A A A
Published online

SESSION TITLE: COPD Phenotypes

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Chronic obstructive pulmonary disease (COPD) phenotypes may have individual characteristics and different responses to corticosteroids treatment. Recent advances have provided hope for a therapeutic strategy that restores corticosteroid sensitivity by increasing histone deacetylase-2 activity by low-dose theophylline. We conducted a study to identify phenotypes with good responses to inhaled corticosteroids by high-resolution computed tomography (HRCT) and explored the effect of low-dose theophylline on corticosteroid sensitivity.

METHODS: Sixty-three stable COPD patients were examined by HRCT and classified into three phenotypes: absence of emphysema, with little emphysema with or without bronchial wall thickening (A phenotype), emphysema without bronchial wall thickening (E phenotype), and emphysema with bronchial wall thickening (M phenotype). They were treated with fluticasone propionate/salmeterol with or without theophylline for twenty-four week follow-up.

RESULTS: The patients of phenotype A and M responded well to corticosteroid treatment, whereas patients of phenotype E responded poorly. Anti-inflammatory sensitivity of inhaled corticosteroid was increased in the phenotype E treated with low-dose theophylline combination therapy.

CONCLUSIONS: Low-dose theophylline may improve the corticosteroids sensitivitiy based on HRCT phenotypes of COPD.

CLINICAL IMPLICATIONS: COPD phenotypes may have individual characteristics and different responses to corticosteroids treatment. Low-dose theophylline may improve the corticosteroids sensitivitiy based on HRCT phenotypes of COPD.

DISCLOSURE: The following authors have nothing to disclose: Xian Wen Sun, Qing Yun Li, Shu Yi Gu, HuanYing Wan, Shao Guang Huang

No Product/Research Disclosure Information


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543