SESSION TITLE: COPD Phenotypes
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: To explore the clinical phenotypes of airways disease by two-step cluster analysis.
METHODS: A population sample of adults who had wheeze within the last 12 months underwent detailed investigation, includingaclinical questionnaire, pulmonary function tests, blood tests (total serum IgE levels and blood eosinophil level) anda peak flow diary. Cluster analysis was carried out on the data set with the subjects defined as described using the following nine variables: 1) pre-bronchodilator FEV1/FVC ratio expressed as a percentage; 2) pre-bronchodilator FEV1 expressed as a percentage of the predicted value; 3) post-bronchodilator change in FEV1, expressed as percentage from baseline; 4) residual capacity expressed as a percentage of the predicted value; 5) diffusing capacity of the lung for carbon monoxide/alveolar volume adjusted for haemoglobin level and expressed as a percentage of the predicted value; 6) the variability of PEF; 7) the serum IgE level; 8) cumulative tobacco cigarette consumption; 9) respiratory symptoms.