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Obstructive Lung Diseases: COPD Phenotypes |

Exploratory Study of the Clinical Phenotypes of Obstructive Disease by Two-Step Cluster Analysis FREE TO VIEW

Pu Ning, MA; Yanfei Guo, PhD
Author and Funding Information

Beijing Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A396. doi:10.1016/j.chest.2016.02.411
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SESSION TITLE: COPD Phenotypes

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To explore the clinical phenotypes of airways disease by two-step cluster analysis.

METHODS: A population sample of adults who had wheeze within the last 12 months underwent detailed investigation, includingaclinical questionnaire, pulmonary function tests, blood tests (total serum IgE levels and blood eosinophil level) anda peak flow diary. Cluster analysis was carried out on the data set with the subjects defined as described using the following nine variables: 1) pre-bronchodilator FEV1/FVC ratio expressed as a percentage; 2) pre-bronchodilator FEV1 expressed as a percentage of the predicted value; 3) post-bronchodilator change in FEV1, expressed as percentage from baseline; 4) residual capacity expressed as a percentage of the predicted value; 5) diffusing capacity of the lung for carbon monoxide/alveolar volume adjusted for haemoglobin level and expressed as a percentage of the predicted value; 6) the variability of PEF; 7) the serum IgE level; 8) cumulative tobacco cigarette consumption; 9) respiratory symptoms.

RESULTS: Four clusters were identified by two-step cluster analysis as follows: cluster 1: chronic obstructive pulmonary disease patients with moderate to severe airflow limitation; cluster 2: asthma-chronic obstructive pulmonary disease overlap syndrome patients with heavy smoking, airflow limitation and increased airways reversibility; cluster 3: patients who had a small amount of smoking and normal pulmonary function with wheeze but no chronic cough; cluster 4: chronic bronchitis patients with normal pulmonary function but had chronic cough.

CONCLUSIONS: Distinct phenotypes of airways disease are identified by cluster analysis; the phenotype of asthma-COPD overlap syndrome have severe airflow obstruction, obvious airway reversibility and poor quality of life.

CLINICAL IMPLICATIONS: Our study identified distinct phenotypes of airways disease by cluster analysis, and confirmed that the phenotype of asthma-COPD overlap syndrome have severe airflow obstruction, obvious airway reversibility and poor quality oflife.

DISCLOSURE: The following authors have nothing to disclose: Pu Ning, Yanfei Guo

No Product/Research Disclosure Information


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