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Obstructive Lung Diseases: COPD Phenotypes |

Exploratory Study of the Clinical Phenotype of Airways Disease by Different Cluster Analysis Methods

Pu Ning, MA; Yanfei Guo, PhD
Author and Funding Information

Beijing Hospital, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A395. doi:10.1016/j.chest.2016.02.410
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SESSION TITLE: COPD Phenotypes

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To explore the clinical phenotype of airways disease by hierarchical cluster analysis and two-step cluster analysis.

METHODS: A population sample of adults who had wheeze within the last 12 months underwent detailed investigation, including a clinical questionnaire, pulmonary function tests, blood tests (total serum IgE levels and blood eosinophil level) and a peak flow diary. Cluster analysis was carried out on the data set with the subjects defined as described using the following nine variables: 1) pre-bronchodilator FEV1/FVC ratio expressed as a percentage; 2) pre-bronchodilator FEV1 expressed as a percentage of the predicted value; 3) post-bronchodilator change in FEV1, expressed as percentage from baseline; 4) residual capacity expressed as a percentage of the predicted value; 5) diffusing capacity of the lung for carbon monoxide/alveolar volume adjusted for haemoglobin level and expressed as a percentage of the predicted value; 6) the serum IgE level; 7) the variability of PEF; 8) respiratory symptoms; 9) cumulative tobacco cigarette consumption.

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