Obstructive Lung Diseases: COPD Pharmacotherapy |

Effects of Aclidinium on Nocturnal Oxygen Saturation of COPD Patients (B-C Stages) FREE TO VIEW

Giuseppe Fiorentino, PhD; Anna Annunziata, PhD; Gianfranco Scotto di Frega, PhD; Rosa Cauteruccio, PhD; Antonella Marotta, PhD; Mariantonietta Mazza, PhD
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Monaldi Hospital, Naples, Italy

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A388. doi:10.1016/j.chest.2016.02.403
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SESSION TITLE: COPD Pharmacotherapy

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To evaluate the effectiveness of the aclidinium bromide (322 mcg twice a day) in improving nocturnal oxygen saturation in COPD patients (B-C stages).

METHODS: We examined 100 patients, all affected by the same COPD severity according to GOLD guidelines (B-C stages). All patients, at the enrolment, filled in a questionnaire on the presence of the following symptoms: a) excessive daytime sleepiness; b) choking or gaspingduring sleep; c) recurrent awakenings from sleep; d) unrefreshing sleep; e) daytime fatigue; f) morning headaches; g) nicturia. We studied the nocturnal oxygen saturation of patients who presented symptoms. 45 patients had sleep disordered breathing with desaturation. All 45 patients were treated aclidinium bromide (322 mcg twice a day). Patients were re-evaluated after 15 days of treatment.

RESULTS: The results, after 15 days of treatment, showed a significant improvement of all parameters examined, particularly of saturation time under 90%. All patients have reported improvement in daytime symptomatology.

CONCLUSIONS: Our study suggest a positive role of aclidinium bromide in improving nocturnal oxygen saturation in patient with COPD.

CLINICAL IMPLICATIONS: Anticholinergic drugs, commonly used in COPD treatment for the bronchodilation improving, were studied in the last years about their effectiveness in sleeping oxygen desaturations. The quality of life is significantly worse in COPD patients with sleep disorders. Therefore the improvement of the nocturnal oxygen saturation is a necessary objective. The study is ongoing, and further evaluation is needed to confirm results.

DISCLOSURE: The following authors have nothing to disclose: Giuseppe Fiorentino, Anna Annunziata, Gianfranco Scotto di Frega, Rosa Cauteruccio, Antonella Marotta, Mariantonietta Mazza

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