METHODS: Twenty four rats were randomly divided into three groups: a normal control group (n = 8), an autoimmune emphysema model group (n = 8) and an intervention group (n = 8). Intraperitoneal injection with primary cultured human umbilical vein endothelial cells was given to establish the autoimmune emphysema models, while the intervention group injected intraperitoneally with the same cells and methylprednisolone. The levels of AECA in bronchoalveolar lavage fluid (BALF) were determined using ELISA. Lung tissue section stained by HE was observed, Mean liner intercept (MLI) and mean alveolar numbers (MAN) measured. The expression of VEGFR-2 in the lung was detected using immunohistochemical analysis. TUNEL technique was used to detect the alveolar septal cell apoptosis.