Obstructive Lung Diseases: COPD II |

Serum Surfactant Protein D is a Potential Biomarker of Decline in Lung Function and COPD: A Prospective Pilot Study FREE TO VIEW

Jiping Liao, MD; Xi Wang, MD; Cheng Yuan, MD; Yanni Zhao, MD; Guangfa Wang, MD
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Department of Pulmonary and Critical Care Medicine, Peking University First Hospital, Beijing, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A385. doi:10.1016/j.chest.2016.02.400
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To assess whether changes in serum level of surfactant protein D, correlate with the rate of decline in lung function among elderly population in China.

METHODS: From 2008 to 2011, a prospective cohort study was conducted on 1278 elderly people (aged 40-75y) in an urban community in Beijing. All the participant were free of severe chronic disease, and underwent standard lung function assessment and blood samples collection every 2 years. At last, 96 participants were enrolled into one of three groups: nonsmoking controls, current or ex-smoking controls, and COPD patients. The serum level of surfactant protein D (SP-D) were measured.

RESULTS: COPD group had more male (14/21 vs 28/75) and elderly participants (mean age 63y vs 57y) than non-COPD control groups. The baseline concentration of SP-D, body mass index, smoking (pack-years) were comparable. The overall trends observed in levels of SP-D in serum were increased in COPD and smoking control group (p<0.01), and forced expiratory volume in one second (FEV1) decreased in all groups. The rate of decline in FEV1 seemed higher in COPD patients than non-COPD control groups, but without statistical significance. After controlling for age, sex, height, body mass index, smoking, baseline level of SP-D, we found increase in SP-D is correlated with the rate of decline of FEV1 in all groups (r=0.309, p=0.005).

CONCLUSIONS: Increase in concentration of serum SP-D correlated with the rate of decline in FEV1 in elderly population, especially in COPD and smokers.

CLINICAL IMPLICATIONS: SP-D may be a potential biomarker of COPD.

DISCLOSURE: The following authors have nothing to disclose: Jiping Liao, Xi Wang, Cheng Yuan, Yanni Zhao, Guangfa Wang

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