The First Hospital of Jilin University, Changchun, China
Copyright 2016, American College of Chest Physicians. All Rights Reserved.
SESSION TITLE: COPD II
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: In order to verify the role of NK cells and NKT cells in COPD patients, we detected the numbers of CD3 − CD56 +Nkcells andCD3 + CD56 + NKT-like cells from the peripheral blood of COPD patients and compared their values with those in healthy nonsmokers (HNS) who acted as controls.
METHODS: In the present study,19COPD patients and 12 healthy nonsmokers (HNS) were recruited, and their pulmonary function was assessed. The frequencies of CD3 + T, CD4 + T, CD8 + T, B, NK, and NKT-like cells were determined using flow cytometry.
RESULTS: The potential association of lymphocyte subsets with disease severity was further analyzed. Significantly decreased numbers of CD3 + and CD4 + T cells, and the CD4 + /CD8 + ratio, but increased numbers of CD3 − CD56 + NK and CD3 + CD56 +NKT-like cells were observed in COPD patients compared to HNS. The frequencies of inducible IFN-γ-secreting NK and NKT-like cells were less in COPD patients. The frequencies of CD158a and CD158b on NK cells and CD158b on NKT-like cells were greater. The frequency of CD158b + NK cells was negatively correlated with FEV 1% prediction and FEV 1 /FVC. Our data indicate that COPD patients have immune dysfunction, and higher frequencies of inhibitory NK cells and NKT-like cells may participate in the pathogenesis of COPD.
CONCLUSIONS: In conclusion, our data indicate that there is an imbalance of immune function in COPD patients. Increased numbers of NK cells and NKT-like cells expressing inhibitory receptors may participate in the pathogenesis of COPD, and the frequency of CD158b + NK cells may reflect the severity of COPD to a certain extent.
CLINICAL IMPLICATIONS: In order to verify the role of NK cells and NKT cells in COPD patients, we detected the numbers of CD3 − CD56 +Nkcells andCD3 + CD56 + NKT-like cells from the peripheral blood of COPD patients and compared their values with those in healthy nonsmokers (HNS) who acted as controls.
DISCLOSURE: The following authors have nothing to disclose: Ying Tang
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