0
Obstructive Lung Diseases: COPD II |

Increased Numbers of NK Cells, NKT-Like Cells, and NK Inhibitory Receptors in Peripheral Blood of Patients With Chronic Obstructive Pulmonary Disease FREE TO VIEW

Ying Tang
Author and Funding Information

The First Hospital of Jilin University, Changchun, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A380. doi:10.1016/j.chest.2016.02.395
Text Size: A A A
Published online

SESSION TITLE: COPD II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: In order to verify the role of NK cells and NKT cells in COPD patients, we detected the numbers of CD3 − CD56 +Nkcells andCD3 + CD56 + NKT-like cells from the peripheral blood of COPD patients and compared their values with those in healthy nonsmokers (HNS) who acted as controls.

METHODS: In the present study,19COPD patients and 12 healthy nonsmokers (HNS) were recruited, and their pulmonary function was assessed. The frequencies of CD3 + T, CD4 + T, CD8 + T, B, NK, and NKT-like cells were determined using flow cytometry.

RESULTS: The potential association of lymphocyte subsets with disease severity was further analyzed. Significantly decreased numbers of CD3 + and CD4 + T cells, and the CD4 + /CD8 + ratio, but increased numbers of CD3 − CD56 + NK and CD3 + CD56 +NKT-like cells were observed in COPD patients compared to HNS. The frequencies of inducible IFN-γ-secreting NK and NKT-like cells were less in COPD patients. The frequencies of CD158a and CD158b on NK cells and CD158b on NKT-like cells were greater. The frequency of CD158b + NK cells was negatively correlated with FEV 1% prediction and FEV 1 /FVC. Our data indicate that COPD patients have immune dysfunction, and higher frequencies of inhibitory NK cells and NKT-like cells may participate in the pathogenesis of COPD.

CONCLUSIONS: In conclusion, our data indicate that there is an imbalance of immune function in COPD patients. Increased numbers of NK cells and NKT-like cells expressing inhibitory receptors may participate in the pathogenesis of COPD, and the frequency of CD158b + NK cells may reflect the severity of COPD to a certain extent.

CLINICAL IMPLICATIONS: In order to verify the role of NK cells and NKT cells in COPD patients, we detected the numbers of CD3 − CD56 +Nkcells andCD3 + CD56 + NKT-like cells from the peripheral blood of COPD patients and compared their values with those in healthy nonsmokers (HNS) who acted as controls.

DISCLOSURE: The following authors have nothing to disclose: Ying Tang

No Product/Research Disclosure Information


Figures

Tables

References

NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).

Some tools below are only available to our subscribers or users with an online account.

Related Content

Customize your page view by dragging & repositioning the boxes below.

Find Similar Articles
CHEST Journal Articles
PubMed Articles
  • CHEST Journal
    Print ISSN: 0012-3692
    Online ISSN: 1931-3543