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Obstructive Lung Diseases: COPD II |

IL-17A Is Elevated in Patients With Chronic Obstructive Pulmonary Disease and Contributes to Airway Remodeling by Acting on Fibroblasts

Tianwen Lai, PhD; Bao-ping Tian, PhD; Chao Zhang, PhD; Yue Hu, PhD; Luanqing Che, PhD; Feng Xu, PhD; Songmin Ying, PhD; Wen Li, PhD; Zhihua Chen, PhD; Huahao Shen, PhD
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Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A379. doi:10.1016/j.chest.2016.02.394
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SESSION TITLE: COPD II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Recent studies suggest that has been implicated in the pathogenesis of various inflammatory diseases. It is currently unknown, however, whether YKL-40 plays a role in COPD airway remodeling.

METHODS: Here, we evaluated IL-17A expression in the lung of patients with COPD and smokers without COPD, as well as in controls. The association between IL-17A expression and airway remodeling was analyzed. In parallel, IL-17A-/- mice and wild-type control animals were exposed to cigarette smoke for 3 months, and airway inflammation and airway remodeling were assessed. The effects of IL-17A on collagen synthesis of primary human lung fibroblasts were also evaluated.

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