Obstructive Lung Diseases: COPD I |

Number of Pack Year Smoked Increases Arterial Pco2 Level in Patients With COPD FREE TO VIEW

Mohit Bhatia, MD
Author and Funding Information

Institute of Medical Sciences, Varanasi, India

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A371. doi:10.1016/j.chest.2016.02.386
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Smoking is the most important risk factor involved in pathogenesis of COPD. Quantification of the risk due to smoking has done in form of pack year. Due to abnormal distribution of ventilation, and ventilation-perfusion mismatch patients with COPD have tendency to retain CO2. In our study we tried to find correlation between increase quantity of risk factor (pack years) with arterial blood gas Pco2 levels in stable COPD patients.

METHODS: In our study we evaluated 50 patients of COPD (post bronchodilator FEV1/FVC< 0.70). We only included stable patients and excluded the patients presented with acute exacerbation (with or without type 2 respiratory failure). Number of pack years calculated for each patient. Now we further excluded patients with 0 pack year, as some of the non-smokers had other risk factors like exposure to biomass fuel etc. which were difficult to quantify. Pco2 levels were obtained via arterial blood gas analysis. Obtained data analysed statistically to calculate Pearson product-moment correlation coefficient with the help of SPSS software.

RESULTS: In our study we found that there is significant positive correlation between no. of pack year smoke and Pco2 levels. We got Pearson product-moment correlation coefficient (r) = 0.387 and a significant p-value = <0.005.

CONCLUSIONS: Total number of pack year smoked has significant positive correlation with arterial Pco2 levels. As the quantity of risk factor (pack years) increases, arterial Pco2 levels also increases.

CLINICAL IMPLICATIONS: As we concluded with the increase in quantity of risk factor (pack year) arterial pco2 levels increases and these patient will have more risk to develope hypercapnic respiratory failiure. patient with higher number of pack year should have more frequent arterial blood gas monitoring, and timely advise for non invassive ventilation will reduce the risk of hypercapnic respiratory failiure.

DISCLOSURE: The following authors have nothing to disclose: Mohit Bhatia

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