Obstructive Lung Diseases: COPD I |

Silent Aspiration in Patients with Exacerbation of Chronic Obstructive Pulmonary Disease FREE TO VIEW

Rongchang Chen, PhD; Zheng Zeguang, PhD; Zhida Wu, MS; Ni Liu, MS; Ping Chen, MS; Peng Hou, MS
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First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A367. doi:10.1016/j.chest.2016.02.382
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: We sought to determine the prevalence and clinical consequences of saliva aspiration on acute exacerbation of chronic obstructive pulmonary disease.

METHODS: Forty-two patients admitted to our hospital because of acute exacerbation of chronic obstructive pulmonary disease were included in this study. Thirteen age-matched healthy volunteers were recruited as a control group. In addition to medical history, physical examination, and laboratory analysis, salivary scintigraphy was performed to evaluate saliva aspiration.

RESULTS: The silent aspiration rate was 14/42 (33.33%) in the patient group and 0/13 in the control group, as determined by salivary scintigraphy. Among the 14 patients with positive silent aspiration, 12 had two or more acute exacerbations in the previous year, which was significantly higher than that in patients with negative silent aspiration (10/28, P = 0.03). Logistic analysis revealed that the modified Medical Research Council dyspnoea scale score was associated with an increased risk of silent aspiration (P = 0.030; OR, 2.141; 95% CI, 1.078-4.25)

CONCLUSIONS: The high silent aspiration rate in individuals with chronic obstructive pulmonary disease was associated with frequent exacerbation in the previous year and increased infection-related acute exacerbation, indicating that silent aspiration affected the frequency of acute exacerbation in patients with chronic obstructive pulmonary disease.

CLINICAL IMPLICATIONS: We will provide a new ideas for COPD exacerbations etiology

DISCLOSURE: The following authors have nothing to disclose: Rongchang Chen, Zheng Zeguang, Zhida Wu, Ni Liu, Ping Chen, Peng Hou

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