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Obstructive Lung Diseases: COPD Exacerbations |

Prevalence and Risk Factors of Viral Infection in Hospitalized Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease FREE TO VIEW

Yu-wen Luo; Yun Li; Jingjing Zheng; Song-wen Guo; Xin Chen, MD
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Southern Medical University, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A363. doi:10.1016/j.chest.2016.02.378
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SESSION TITLE: COPD Exacerbations

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To detect the virus using Ploymerase Chain Reaction (PCR) technology in the hospitalized patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and investigate prevalence of viral infection and the risk factors for AECOPD.

METHODS: We did a retrospective investigation of patients with AECOPD from May 2012 to May 2015, collected patient’s basic information, clinical data and length of hospital stay, and analysis the virus epidemiology by using PCR. A logistic regression analysis was performed to investigate the risk factors.

RESULTS: 127 patients with AECOPD were included in this study. 52 episodes (40.94%) yielded positive viral PCR results, only one virus infection 36 episodes (28.34%), mixed infection 16 episodes (12.60%). AECOPD patients with a viral infection were associated with longer hospital stay (11.5 ± 0.96 vs 8.99 ± 0.42, P = 0.000). Multiple regression analysis showed that smoking (P=0.029), diabetes (P=0.001), respiratory failure (P=0.049), frequency of exacerbations in previous year (P=0.028) were the risk factors.

CONCLUSIONS: Prevalence of respiratory viral infections was high in hospitalized patients with AECOPD. The length of hospital stay was longer in AECOPD patients from who a virus was isolated. Smoking, diabetes, respiratory failure, and frequency of exacerbations in previous year were the risk factors of a viral infection.

CLINICAL IMPLICATIONS: Early identification of these risk factors may help reduce the incidence of AECOPD.

DISCLOSURE: Yu-wen Luo: Grant monies (from sources other than industry): The Guangzhou Municipal Science and Technology Project (201300000171) Yun Li: Grant monies (from sources other than industry): The Guangzhou Municipal Science and Technology Project (201300000171) Jingjing Zheng: University grant monies: The Guangzhou Municipal Science and Technology Project (201300000171) Song-wen Guo: Grant monies (from sources other than industry): The Guangzhou Municipal Science and Technology Project (201300000171) Xin Chen: Grant monies (from sources other than industry): The Guangzhou Municipal Science and Technology Project (201300000171)

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