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Obstructive Lung Diseases: COPD Exacerbations |

The Significance of the Inflammatory Response in Chronic Obstructive Pulmonary Disease-Related Pulmonary Hypertension FREE TO VIEW

Jing Dong, MMSc
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Nanjing Chest Hospital, Nanjing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A361. doi:10.1016/j.chest.2016.02.376
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SESSION TITLE: COPD Exacerbations

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate the blood percentage of neutrophils (N%), C-reactive protenin (CRP), proclcitonin (PCT) in chronic obstructive pulmonary disease (COPD) patients with and without pulmonary hypertension (PH), and explore the significance of the inflammatory response in COPD-related PH

METHODS: From November 2013 to April 2015, 72 patients with COPD at acute exacerbation were enrolled in Nanjing Chest hospital, the patients were divided into COPD with PH group and COPD without PH group according to the pulmonary artery systolic pressure (PASP) >>40mmHg, 20 healthy persons were selected as control group at the same period, COPD with PH group and COPD without PH group were detected in serum PCT, CRP levels, white blood cell count and classification (N%) record patients smoking status, comorbidities (heart failure, hypertension, diabetes, etc). To compare the levels of blood N%, CRP and PCT were observed before after treatment, and then analysis the correlation between the blood N%, CRP and PCT levels and PASP.

RESULTS: Compared with the control group before treatment, COPD with PH group serum PCT concentration (0.24 ± 0.43) ng/ml, COPD without PH group serum PCT concentration (0.08 ± 0.07) ng/ml difference was statistically significant. COPD with PH group serum CRP concentration (23.78 ± 42.79) ng/ml, COPD without PH group serum CRP concentration (2.58 ± 2.10) ng/ml difference was statistically significant (p<0.05), COPD in patients with acute exacerbation of PCT and CRP was positively correlated (r=0.63, p<0.05), and peripheral WBC no correlation between length of stay and lower values. After treatment, compared to that before treatment, COPD with PH group serum PCT concentration (0.20+0.08) ng/ml, COPD without PH group serum PCT concentration (0.21 ± 0.15) ng/ml, each group p<0.05, not statistically significant. COPD with PH group serum CRP concentration (25.31 ± 0.73) ng/ml, COPD without PH group serum CRP concentration (22.96 ± 0.96) ng/ml, each group p>0.05, not statistically significant.

CONCLUSIONS: Neutrophils, CRP and PCT were not only involved in the inflammation of airways and lung parenchyma, but also may play a very important role in the formation of COPD -related PH

CLINICAL IMPLICATIONS: The inflammation of airways also may be play a very important role in the formation of COPD -related PH.

DISCLOSURE: The following authors have nothing to disclose: Jing Dong

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