SESSION TITLE: COPD: Etiology
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Mucus hypersecretion is a common pathological feature of chronic airway inflammatory diseases, including asthma, chronic obstructive pulmonary disease (COPD), lung cancer, and cystic fibrosis. Despite numerous studies before, the molecular bases for this condition are still not clear. We have recently demonstrated that cigarette smoking induced autophagy in airway epithelial cells which eventually contributed to the epithelial cell apoptosis and the development of emphysema. In this study, we investigated the relationship between autophagy and mucus expression in context of cigarette smoking-induced airway inflammation.