RESULTS: PM2.5 or CSE treatment significantly decreased the phagocytic activity of MDM from COPD patients and healthy subjects. This inhibiting effect presented more obvious when the two combined. Additionally, the decrease of phagocytic activity was more in COPD MDM compared to healthy subjects. In COPD patients, the MDA content was higher than in healthy subjects, while the TAC level and GSH-PX activity were lower. PM2.5 or/and CSE decreased the MDA content and increased the the TAC level and GSH-PX activity in COPD patients and healthy subjects. This oxidative damage seen in COPD patients was more compared to healthy subjects. There was a negative correlation between the phagocytic activity and the levels of MDA exposured to in PM2.5 or/and CSE, whereas there is a positive correlation between the phagocytic activity and the levels of TAC and GSH-PX activities.