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Obstructive Lung Diseases: COPD: Etiology |

Inhibitory Effects of Corticosteroids on the Smoke-Induced Pulmonary Inflammation is Potentiated by Concomitant Administration of Pentoxifylline or Roflumilast

Dandan Chen, MMed; Luxi Zhou, PhD; Changzhi Zhou, MMed; Ping Wu, PhD; Jinnong Zhang, PhD
Author and Funding Information

WuHan Union Hospital, Tongji Medical College, Huazhong University of Science and Technololgy, Wuhan, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A356. doi:10.1016/j.chest.2016.02.371
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SESSION TITLE: COPD: Etiology

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Chronic obstructive pulmonary disease (COPD) is a disease of inflammation that is commonly induced by chronic exposure of cigarettes smoke. Unlike bronchial asthma, the pulmonary inflammation is insensitive to corticosteroids. The purpose of this study is to investigate if addition of pentoxifylline (PTX) or roflumilast (ROF), the anti-inflammatory effects of corticosteroids would be restored or potentiated.

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