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Obstructive Lung Diseases: COPD: Etiology |

Angiotensin Receptor Blockade Attenuates Cigarette Smoke Extract-Induced Apoptosis of A549 Cells Through Up-Regulation of Nrf2

Ting Li, MD; Xu Li, PhD; Yan Chen, MD; Miaoxia Pan, MD; Liheng Guo, PhD; Ying Meng, PhD
Author and Funding Information

Department of Intensive Care Unit (ICU), Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A355. doi:10.1016/j.chest.2016.02.370
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SESSION TITLE: COPD: Etiology

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Cigarette smoke (CS) is a highly complex mixture and many of its components are known carcinogens, mutagens, and other toxic substances, whici is associated with an increased incidence of chronic obstructive pulmonary disease (COPD). In this study, we hypothesized that Irbesartan, an angiotensin receptor blockade, protected against cigarette smoke extract-induced apoptosis of A549 human lung carcinoma cells by inducing the expression of Nrf2.

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