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Obstructive Lung Diseases: COPD: Etiology |

The Influence of Different Ways of Rearing and Tobacco Smoke Exposure to Rat’s Emphysema and the Atherosclerosis Formation and Interaction Research

Hu Liu
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Shanxi Dayi Hostpital, Shanxi, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A354. doi:10.1016/j.chest.2016.02.369
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SESSION TITLE: COPD: Etiology

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To explore the relationship of rat’s emphysema induced by different ways of rearing and tobacco smoke exposure and the atherosclerosis formation, and its possible mechanism.

METHODS: Ninety 6-week clean male SD rats [wight(200±20) g] were randomly divded into normal diet + tobacco smoke exposure group, fat-rich diet + tobacco smoke exposure group, limit intake + tobacco smoke exposure group, normal diet group, fat-rich diet group, and limit intake group. The relevant indices were measured in each groups after 24 weeks. Lee’s index was calculated. The serum TNF-α, IL-6 and adiponectin (APN) levels were detected by ELISA kits. Mean linear intercept (MLI) and mean alveoli number (MAN) were calculated and the aortic pathology change was observed by the microscope. Aortic vascular VEGF and BMP-2 levels were reflected by immunohistochemical method.

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