METHODS: ①Three extracts, namely petroleum ether extraction (PEE), ethyl acetate extraction (EAE), n-Butyl alcohol extraction (NBAE) and residue extraction (RE), were obtained from Schisandra chinensis by Polarity gradient extraction method. Guinea pigs exposed to successive periods of cigarette smoke (CS) for 14 days (twice a day, 10 cigarettes, 20 min in the morning or afternoon, respectively). During the modeling period, animals were daily oral administrated with three extracts respectively. Citric acid challenge and Biopsy specimens taken were followed in 15th and 16th day. ②A549 cells were proliferated for 24 h. The cells were incubated separately with various concentrations of schizandrin, schisantherin A, deoxyschizandrin, γ-schisandrin, 1 h followed by treatment with 2% CSE for another 1 h. The mRNA expression of TRPV1 and TRPA1 were detected by real time PCR.