SESSION TITLE: COPD: Etiology
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Chronic obstructive pulmonary disease (COPD) is a prevalent smoking-related disease for which no disease altering therapies currently exist. The angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7) [Ang(1-7)]/Mas axis, which counteracts the angiotensin-converting enzyme (ACE)/angiotensin II (AngII)/angiotensin II type 1 receptor (AT1R) axis, has been shown to attenuate cigarette smoke-induced lung injury. Nevertheless, the exact molecular mechanism remains unclear. The present study evaluated the protective effects of the ACE2/Ang(1-7)/Mas axis on cigarette smoke-induced apoptosis of alveolar epithelial cells by inhibiting the NOX4-derived ROS-mediated JNK-Bax-caspase3 pathway.