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Obstructive Lung Diseases: COPD |

Fat Free Mass Index for Evaluating the Nutritional Status and Disease Severity in COPD FREE TO VIEW

Xin Chen; Yu-wen Luo; Yun Li; Song-wen Guo; Rui Chen; Lu-qian Zhou
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Southern Medical University, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A348. doi:10.1016/j.chest.2016.02.363
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SESSION TITLE: COPD

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 09:45 AM - 11:15 AM

PURPOSE: Despite high prevalence of weight loss in patients with chronic obstructive pulmonary disease (COPD), the recent 2011 COPD management guidelines do not include an index measuring the nutritional status. Fat free mass index (FFMI) can accurately determine the nutritional status of patients and may be closely correlated with the COPD severity. We aimed to determine the nutritional status evaluated by FFMI according to the 2011 GOLD levels in stable COPD patients and the association between nutritional status and respiratory symptoms, exercise capacity, and respiratory muscle function.

METHODS: We included 235 stable COPD patients in this cross-sectional study. FFMI (measured by bioelectrical impedance), spirometry (forced expiratory volume in 1 s [FEV1], FEV1 percent predicted [FEV1%pred], and FEV1/FVC), respiratory muscle function (peak inspiratory and peak expiratory pressures), exercise capacity (6-minute walk distance [6MWD]), and dyspnea severity (mMRC) were measured and compared between the GOLD groups.

RESULTS: Malnutrition was identified in 48.5% of patients and most prevalent in Group D (Group A: 41%, Group B: 41%, Group C: 31%, and Group D: 62%). FFMI was significantly lower in Group D (P<0.001), with both genders considered malnourished. Low FFMI significantly correlated with frequent exacerbation, older age, decreased pulmonary function, 6MWD, peak inspiratory pressure, and worsened dyspnea.

CONCLUSIONS: Malnutrition is highly prevalent in all COPD groups, particularly in Group D patients, who warrant special attention for nutritional intervention and pulmonary rehabilitation. FFMI significantly correlated with the exercise capacity, dyspnea, respiratory muscle function, and pulmonary function, and may be a useful predictor of COPD severity.

CLINICAL IMPLICATIONS: Our results suggest that the recent COPD management guidelines should include an index measuring the nutritional status, such as FFMI, which is also a useful predictor of COPD severity.

DISCLOSURE: Xin Chen: Grant monies (from sources other than industry): The Guangdong Provincial Science and Technology Project (2013B022000072) Yu-wen Luo: Grant monies (from sources other than industry): The Guangdong Provincial Science and Technology Project (2013B022000072) Yun Li: Grant monies (from sources other than industry): The Guangdong Provincial Science and Technology Project (2013B022000072) Song-wen Guo: Grant monies (from sources other than industry): The Guangdong Provincial Science and Technology Project (2013B022000072) Rui Chen: Grant monies (from sources other than industry): The Guangdong Provincial Science and Technology Project (2013B022000072) Lu-qian Zhou: Grant monies (from sources other than industry): The Guangdong Provincial Science and Technology Project (2013B022000072)

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