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Obstructive Lung Diseases: COPD |

The Efficacy of Non-Invasive Mechanical Ventilation as a Rescue Therapy for Relieving Dyspnea in Patients With Stable Severe COPD

Yonger Ou, PhD; Zhimin Lin; Weiliang Wu; Qun Luo; Rongchang Chen
Author and Funding Information

National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Disease, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A347. doi:10.1016/j.chest.2016.02.362
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SESSION TITLE: COPD

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Sunday, April 17, 2016 at 09:45 AM - 11:15 AM

PURPOSE: The purpose of this study was to evaluate the effectiveness of NIV as rescue therapy in relieving exertional dyspnea in stable severe COPD patients.

METHODS: This was a randomized crossover study in 18 male patients with stable severe-to-very severe COPD (mean ± SD FEV1: 29.5 ± 6.9% predicted). Exertional dyspnea was induced with maximal symptom-limited incremental cycle exercise. Then the patients would randomly receive oxygen therapy or NIV plus oxygen therapy. Patients were crossed to another therapy group in the second day. During the whole process, HR, SpO2 and breathing pattern were monitored continuously until complete recovery. At every 30s interval, inspiratory capacity (IC) and severity of dyspnea (Borg scale) were assessed. Changes in IC, ventilation, breathing pattern, dyspnea intensity and total dyspnea recovery time were compared between two interventions.

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