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Lung Cancer: Mechanisms of Lung Cancer |

Osteopontin Induces Epithelial-to-Mesenchymal Transitions in Human Lung Cancer Cells via PI3K/Akt and MEK/Erk1/2 Signaling Pathways

Lin Shi; Lin Wang; Xiang Wang
Author and Funding Information

Zhongshan Hospital, Fudan University Medical School; Shanghai Institute of Clinical Bioinformatics, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A332. doi:10.1016/j.chest.2016.02.345
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SESSION TITLE: Mechanisms of Lung Cancer

SESSION TYPE: Original Investigation Slide

PRESENTED ON: Saturday, April 16, 2016 at 02:15 PM - 03:45 PM

PURPOSE: A multifunctional protein known as Osteopontin (OPN) has an important, yet poorly understood role in Non-Small Cell Lung Cancer (NSCLC) pathogenesis. OPN was reported to be associated with the epithelial-to-mesenchymal transition (EMT) of cells, promoting tumor cells metastasis, but its mechanism remains unclear.

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