SESSION TITLE: Mechanisms of Lung Cancer
SESSION TYPE: Original Investigation Slide
PRESENTED ON: Saturday, April 16, 2016 at 02:15 PM - 03:45 PM
PURPOSE: Lung adenocarcinoma has one of the highest morbidity and mortality rates of any cancer worldwide. Our previous studies have demonstrated that progesterone can inhibit lung adenocarcinoma A549 cells proliferation, migration and invasion in combination with Src inhibitor PP1, improve chemo-sensitivity to Gefitinib via a membrane progesterone receptor mechanism. Long noncoding RNAs (lncRNAs) have been shown to play essential roles in some types of cancer; however, the contributions of lncRNAs to progesterone-associated mechanisms in lung adenocarcinoma remain unknown.