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Lung Cancer: Lung Cancer IV |

Clinical Significance of EpCAM in Circulating Tumor Cells in the Peripheral Blood During Adjuvant Therapy for Postoperative Non-small Cell Lung Cancer Patients

Zhidong Liu, PhD; Dezhi Zhen, MD; Yunsong Li, MD; Chongyu Su, MD; Kang Shi, MD; Shijie Zhou, MD; Shuku Liu, PhD; Yi Han, MD; Daping Yu, MD; Xiaoyun Song, MD; Ning Xiao, MD; Xiaoqing Cao, PhD
Author and Funding Information

Department of Thoracic Surgery, Beijing Chest Hospital, Capital Medical University, Beijing, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A325. doi:10.1016/j.chest.2016.02.338
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SESSION TITLE: Lung Cancer IV

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: NSCLC is one of the severest malignancies dangerous for human’s health, whose morbidity and mortality are both highly increasing in all countries. Operative resection and postoperative adjuvant treatment are the best choice. The effect of adjuvant treatment depends on imaging tests. However, the patient was already in stage IV when recurrences or metastases were found by imaging tests. There are few successful treatment options for stage IV patients and the 5-year survival rate is less than 2%. Therefore, an early indicator on monitoring the therapeutic effects during adjuvant therapy for postoperative NSCLC patients is in need. Studies have showed that CTCs of peripheral blood is an important factor leading to disease progression and exacerbation, and could have diagnostic value in early stage of lung cancer. Therefore, we put forward hypothesis that EpCAM in CTCs in the peripheral blood can be an early indicator on monitoring the therapeutic effects during adjuvant therapy for postoperative NSCLC patients.

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