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Lung Cancer: Lung Cancer IV |

Adenylate Cyclase-Associated Protein 1 Is Associated With Metastasis of Non-small Cell Lung Cancer Especially in Brain Metastasis Patients and Promotes the Lung Cancer Cell Proliferation and Migration In Vitro as Well as Its Growth and Metastasis In Vivo By the Signaling Pathways of Limk1-Cofilin

Changhui Wang, PhD; Shuanshuan Xie, PhD; Xiaolian Song, PhD; Min Tan, MD
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Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A324. doi:10.1016/j.chest.2016.02.337
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SESSION TITLE: Lung Cancer IV

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: This study was designed to predict non-small cell lung cancer metastasis and explore mechanism of lung cancer cell proliferation, metastasis and migration in vitro and vivo.

METHODS: Firstly, Adenylate cyclase-associated protein 1, CAP1 were determined by real-time PCR and western blot analysis and IHC in 82 lung cancer specimens. Secondly, BM group (n =50) and non-BM group (n =70) were treated and followed up by 4 years. Thirdly, we characterized the expression of CAP1 in lung cell by using Western blot and RT-PCR analyses. In addition, ShCAP1-LV, empty vector, CAP1-LV are cultured with A549, H1299, 95-D by using MTT, wound Healing, Transwell invasive, Western blot, and IHC analyses and nude mouse.

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