Lung Cancer: Lung Cancer III |

Application Progress and Prospect of the Feedback System Control-Based Combinatorial Drug Optimization Technique FREE TO VIEW

Lili Dong
Author and Funding Information

Shanghai Chest Hospital, Shanghai, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A319. doi:10.1016/j.chest.2016.02.332
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: A brief review of the application progress of the FSC technique is presented to provide new ideas for chemotherapy drug screening in non-small cell lung cancer patients.

METHODS: Through searching the literature on PUBMED and consulting experts, some literature is collected and analyed to prepare this review.

RESULTS: The feedback system control based combinatorial drug optimization technique is based on the combination of “engineering feedback control theory” and “biological complex systems”, and it has been successfully applied in the fields of biology and healthcare.

CONCLUSIONS: Instead of high-throughput screening, the FSC technique can identify optimal drug combinations by testing less of all possible combinations, and it will become a potential method of combinatorial drug optimization.

CLINICAL IMPLICATIONS: If the FSC technology is applied to chemotherapy drug screening, it will provide supports for individualized therapy and open a new treatment mode for the patients with malignant tumor.

DISCLOSURE: Lili Dong: Other: Project supported by the National Nature Science Foundation of China (Grant No. 81472175) and Shanghai Municipal Commission of Health and Family Planning Key Projects (Grant No. 20134007)

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