Lung Cancer: Lung Cancer III |

Screening Identification Neovascularization Epitopes of Non-small Cell Lung Cancer FREE TO VIEW

Wei Cheng, PhD; Kun Yan; Zhanwei Feng; Yi Miao; Wen Zhang; Jing Wang
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Xi’an Children Hospital, Xi'an, China

Copyright 2016, American College of Chest Physicians. All Rights Reserved.

Chest. 2016;149(4_S):A317. doi:10.1016/j.chest.2016.02.330
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SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Non-small cell lung cancer (NSLC) is a malignant tumor and counts the most important causes of mortality. Most case were advanced when detected. Neovascularization is a prominent features of it. The antiangiogenic agents were once attractive for individual treatment. But it is easily resistant. Therefore, investigating neovascularizated epitopes interacted most interest. Considering the early diagnosis and follow up surveillance of NSLC are significantly important, it is urgent to discover the epitope to meet the clinical requires. The purpose of this study is to identify discriminating the potential epitope of NSLC.

METHODS: To establish model of NSLC associated neovascularizat by co-culture NSLC cells and endothelial progenitor cells. Screened displayed library in vivo to obtain the epitope of NSLC. The information of epitope biological function and subgroups were preliminary obtain by Bioinformatics methods.

RESULTS: After 4 rounds of selection and analysis, 70 clones were picked up and sequenced individually. And there was at least 13.9 fold increase in NSLC xenograft in comparision with control organs after the phage was injected. They could classify 4 subgroups, early diagnosis, invasiveness (vascular invasion) and aggressiveness, surveillance survival and recurrence, prognosis.

CONCLUSIONS: We successfully carried out 70 epitope. They were accumulated in NSLC. Using computer assist technique, they are classify associated with diagnosis, invasiveness, classify, prognosis.

CLINICAL IMPLICATIONS: This study provide a new approach to identify potential epitope for diagnosis and prognosis of NSLC.

DISCLOSURE: The following authors have nothing to disclose: Wei Cheng, Kun Yan, Zhanwei Feng, Yi Miao, Wen Zhang, Jing Wang

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