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Lung Cancer: Lung Cancer II |

Study on Attenuating Angiogenesis of Pulmonary Malignant Tumor by Targeting FAK Both in vivo and in vitro.

Shun Liu; Lan Pu; Yi Huang; Feng Wu; Ling Gong; Lan Zhu; Qian Chen; Chuan Huang
Author and Funding Information

The Institute of Respiratory Diseases in Zunyi City, The First People's Hospital of Zunyi City, Zunyi, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A311. doi:10.1016/j.chest.2016.02.324
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SESSION TITLE: Lung Cancer II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate the role of Focal Adhesion Kinase (FAK) in angiogenesis of pulmonary malignant tumor in vivo and in vitro.

METHODS: We detected the expression of FAK in human umbilical vein endothelial cells (HUVECs), and we used TAE226, FAK siRNA and analyzed their inhibitory effects on HUVECs in vitro. Tumor xenografts in nude mice were used to examine the in vivo activity of TAE226 and FAK siRNA.

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