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Lung Cancer: Lung Cancer II |

Antiflammin-1 Inhibits the TGF-β1-Induced Epithelial-Mesenchymal Transition in A549 Cells Through ERK Pathway

Wei Liu, PhD; Yang Li, PhD; Si-yuan Tang, PhD; Zi-Qiang Luo, PhD
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Central South University, Changsha, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A309. doi:10.1016/j.chest.2016.02.322
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SESSION TITLE: Lung Cancer II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Epithelial to mesenchymal transition (EMT) is a process by which an epithelial cell alters its phenotype to that of a mesenchymal cell and may play a critical role in the lung fibrosis. Antiflammin-1 (AF-1, MQMKKVLDS) is a synthetic nonapeptide with a similar sequence to the conserved sequence of uteroglobin (UG) secreted by lung Clara cells. Studies suggest that it has many biological functions. Our previous studies indicated that AF-1 could suppress the TGF-β1-induced EMT in A549 cells. This report is the first to demonstrate the cell signal pathway of AF-1 in inhibiting TGF-β1 induced EMT in A549 cells.

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