SESSION TITLE: Lung Cancer II
SESSION TYPE: Original Investigation Poster
PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM
PURPOSE: Epithelial to mesenchymal transition (EMT) is a process by which an epithelial cell alters its phenotype to that of a mesenchymal cell and may play a critical role in the lung fibrosis. Antiflammin-1 (AF-1, MQMKKVLDS) is a synthetic nonapeptide with a similar sequence to the conserved sequence of uteroglobin (UG) secreted by lung Clara cells. Studies suggest that it has many biological functions. Our previous studies indicated that AF-1 could suppress the TGF-β1-induced EMT in A549 cells. This report is the first to demonstrate the cell signal pathway of AF-1 in inhibiting TGF-β1 induced EMT in A549 cells.