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Lung Cancer: Lung Cancer II |

The Prediction and Identification of HLA-A*0201 Restricted CTL Epitopes Derived from SOX2 Gene Famil

Yu Wang, MMed; Jingyan Yuan, MB; Jingyuan Xiao, MB; Wei Li, MMed; Na Fan, MMed; Wenjing Deng, MMed; Boxuan Liu, MB; Ping Fang, PhD; Yujie Zhong, MMed; Shuanying Yang, PhD
Author and Funding Information

The Second Affiliated Hospital, Medical College, Xi’an Jiaotong University, Xi’an, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A308. doi:10.1016/j.chest.2016.02.321
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SESSION TITLE: Lung Cancer II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: Predict and identify the HLA-A*0201 restricted CTL epitopes with the strongest immunogengenicity of SOX2 antigen.

METHODS: Predict and screen the natural epitopes with bioinformatics method. Synthesize peptides in vitro. T2 cells were induced by peptides, and then were used in T2 binding assay. The effective cells were acquired by inducing PBMCs with peptides, and the target cells were acquired by inducing T2 cells with peptides. Then they were used in ELISPOT hIFN-γ and LDH releasing tests.

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