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Lung Cancer: Lung Cancer II |

Inhibition Effects of Metformin and Pemetrexed on the Proliferation, Apoptosis and Migration Capabilities of Non-small Cell Lung Cancer Cell Line A549 in vitro

Yan Zhang, MA
Author and Funding Information

QiLu Hospital of ShanDong, Jinan, China


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A305. doi:10.1016/j.chest.2016.02.318
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SESSION TITLE: Lung Cancer II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: To investigate the effects of metformin and pemetrexed on the proliferation, apoptosis and migration capabilities of non­small cell lung cancer cell A549 in vitro.

METHODS: After A549 cells were treated with metformin and pemetrexed alone, or in combination for different period (24,48,72 h), the inhibition of cell proliferation rate in each groups was measured by CCK8, apoptosis rate was texted by flow cytometry and we can see the different migration capabilities by Wound scratch assay.

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