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Lung Cancer: Lung Cancer II |

The Hedgehog Pathway Inhibitor GDC-0449 Alters the Expression Level of the Pathway Components In Lung Cancer Cell Lines

Fei Tian, PhD; Rosemarie Kiefl; Amanda Tufman, MD; Rudolf Huber, MD
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University Hospital of LMU, Munich, Germany


Copyright 2016, American College of Chest Physicians. All Rights Reserved.


Chest. 2016;149(4_S):A299. doi:10.1016/j.chest.2016.02.312
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SESSION TITLE: Lung Cancer II

SESSION TYPE: Original Investigation Poster

PRESENTED ON: Saturday, April 16, 2016 at 11:45 AM - 12:45 PM

PURPOSE: The hedgehog signaling pathway (Hh) has been shown to be activated in cancer. GDC-0449 (Vismodegib) is a low-molecular Hh pathway inhibitor that binds to and inhibits Hh pathway receptor SMO. Recently, we could show that GDC-0449 is effective in lung cancer cell lines and that combination with cisplatin gives an additional effect. However, no data of the effect of GDC-0449 on Hh pathway component expressions in lung cancer cell lines is available.

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